In 1995, I was introduced to pancreatic cancer by my academic advisor and mentor, Dr. Eric Sandgren, while doing graduate studies at the University of Wisconsin. At the time, Dr. Sandgren was one of only a handful of researchers to have a NIH/NCI grant focused on pancreatic cancer research, and nearly all of my laboratory work was directed on developing models of pancreatic cancer and using existing ones to understand disease development. I became passionate about my research as I learned about this disease, its late detection, and poor prognosis. PanCAN has also made its mark in my career from its earliest beginnings, and especially since 2002, where my volunteering in a TeamHope Affiliate (Northern Illinois) has brought me

eye to eye with patients and their dedicated, driven families and friends. These people (Valerie, Angie, Kim, Linda, Terry, Ed, and Marvin) have touched me the most and encouraged me to keep pushing forward with my research, if not for the present, at least for the next generation. To them and to God, I am truly grateful.

The funds that accompany this award will be used to support a project that will determine if a common genetic mutation in pancreatic cancer (in a gene called Kras) is required for the development and maintenance of both early precancerous lesions (PanINs) and cancer. Findings from this project will help identify the cell types that can give rise to pancreatic cancer and if therapies that target mutations in Kras will be effective at the level of precancer and cancer. By trusting me with this award, PanCAN provides the confidence for me to move forward, the funds with which to begin those endeavors, and the history of success to serve as a template.
Nancy Daly Riordan PanCAN-AACR Career Development Award for Pancreatic Cancer Research